Obesity
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18 to 60 years old; with a BMI of at least 24 kg/m² (and a weight less than 120 kg) who are overweight or obese.
Exclusion criteria
Exclusion criteria: Malignant tumors; active tuberculosis; pregnancy or planning to become pregnant; local metallic foreign bodies (such as coronary stents, metal pins, metal plates, metal joints, metal contraceptive devices, etc.); patients with implanted electronic devices such as pacemakers; increased intracranial pressure; glaucoma; diagnosed with diabetes or laboratory evidence of diabetes at the time of screening; use of weight loss products within the last 3 months (including GLP-1 receptor agonists, orlistat, and other prescription or over-the-counter drugs and herbal formulations); have undergone or are planning to undergo weight loss surgery; patients with hyperthyroidism or hypothyroidism; history of gastrointestinal ulcers or bleeding; severe liver, kidney, and cardiovascular and cerebrovascular diseases; history of filler injections, fat grafting (except for the head and face); severe mental disorders that affect compliance; patients with other clinically significant or unstable systemic diseases, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood glucose;Blood lipids;Fatty liver; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;weight;Waist circumference;Hip circumference;Body fat percentage;Blood pressure;heart rate;Body temperature;Brown adipose tissue area;Leptin;Adiponectin;IGF-1;IGFBP3;GIP;Peptide YY,;Cholecystokinin;Ghrelin;Motilin;TSH;FT3;FT4;C-reactive protein;Neuropeptide Y;Body composition; | — |
Countries
China
Contacts
Institute and department of Endocrinology and Metabolism Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University