Perinatal depression
Conditions
Interventions
Ketamine group:Pregnant women with an average of less than 3000 exercise steps per day during mid pregnancy should be given a small dose of 0.2 mg/kg of ketamine immediately after the delivery of the
Exercise group:Pregnant women who exercise an average of more than 3500 steps per day during mid pregnancy should receive an equal amount of physiological saline injection at the same time during surg
Sponsors
Anhui Wanbei Coal-Electricity Group General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) Female patients aged 18-45, middle-aged and young; (2) ASA grades I-III; (3) Prenatal BMI 18.5-29.9kg/m2; (4) Planned cesarean section surgery under lumbar epidural anesthesia (gestational age>37 weeks);
Exclusion criteria
Exclusion criteria: (1) History of cerebrovascular surgery in the past; Patients with important organ dysfunction such as liver, kidney, and lung; (2) History of drug and alcohol abuse, recent use of sedatives, antidepressants, or opioids; (3) Patients with mental illness, intellectual disabilities, or inability to communicate and cooperate; (4) History of severe sleep disorders or chronic pain; (5) Long term perioperative use of NSAIDs; (6) Patients with sudden events such as severe bleeding and arrhythmia during surgery; (7) Patients with diseases such as hyperthyroidism, preeclampsia, eclampsia, placenta previa, or placental abruption; (8) Patients with contraindications for combined spinal and epidural anesthesia; (9) Patients who have participated in other clinical studies; (10) Those who cannot comply with the research protocol and procedures and withdraw midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Edinburgh Postnatal Depression Scale scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale Pain Score;Depression related factors in cerebrospinal fluid and blood;Glutamate concentration in brain regions;The incidence of nausea and vomiting, as well as the incidence of other adverse reactions; | — |
Countries
China
Contacts
Public ContactWang Xianfeng
Anhui Wanbei Coal-Electricity Group General Hospital
Outcome results
None listed