Helicobacter pylori infection
Conditions
Interventions
Low-dose doublet group:Amoxicillin (1 g bid) Tegolasan (50 mg tid) for 14 days
High-dose doublet group:Amoxicillin (1 g tid) Tegolasan (50 mg tid), 14 days
Bismuth tetrapty group:Amoxicillin (1 g bid) Clarithromycin (500 mg bid) Neixin (20 mg bid) Livzon Dele (220 mg bid), 14 days
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–70 years; 2.H. pylori-infected subjects ages without eradication history; 3.The confirmation of H. pylori-infected was evaluated by by positive 13C urea breath test; 4.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.H. pylori-infected subjects ages with eradication history; 2.allergy to amoxicillin or other drugs in the study; 3.Zollinger-Ellison syndrome; 4.acute upper gastrointestinal bleeding, gastric cancer, or other tumors;qid; 5.history of gastric surgery; 6.serious illness including neurological, cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urological, endocrinological or hematological disorders; 7.With serious abnormal liver or renal function; 8.proton pump inhibitors and antibiotics used within one month; 9.pregnancy or lactating women; 10.participated in other clinical trials within 30 days before screening; 11.other factors were considered not suitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The efficacy of therapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events;Compliance;Clarithromycin resistance rate;Levofloxacin resistance rate;Factors influencing the efficacy of eradication;Effects of gut microbiota; | — |
Countries
China
Contacts
Public ContactYin Zhu
The first affiliated hostipal of nanchang university
Outcome results
None listed