postoperative cognitive dysfunction
Conditions
Interventions
Control group:No intervention
Low dose dexmedetomidine group:A loading dose of 0.5µg/kg dexmedetomidine was injected intravenously 10 min before induction, and a rate of 0.2µg/(kg·h) was injected intraoperatively until 40min befor
High dose dexmedetomidine group:A loading dose of 0.5µg/kg dexmedetomidine was injected intravenously 10 min before induction, and a rate of 0.5µg/(kg·h) was injected intraoperatively until 40min befo
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age =60 years old (2) Patients undergoing elective cervical surgery (3) ASA grade I-III (4) Those who agree to participate in the experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Preoperative use of radiotherapy, chemotherapy, anti-inflammatory drugs, analgesics, and hormone drugs; (2) Those with a history of psychotropic drugs, opioids, and alcohol dependence (3) Severe cardiovascular and cerebrovascular diseases, kidney and liver diseases (4) Communication barriers (5) Preoperative basal heart rate< 60 beats/min (6) Those with mental dysfunction before surgery (7) Uncontrolled or poorly controlled hypertension (arterial hypertension, resting systolic/diastolic blood pressure exceeding 180/100mmHg) before surgery (8) Patients with intracranial hypertension, intraocular hypertension, or glaucoma (9) Allergy to dexmedetomidine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MOCA;Heart rate;Sleep quality score;Postoperative adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| MOCA;Mean arterial pressure;Pain scores;Depression scores; | — |
Countries
China
Contacts
Public ContactZhao Wenjing
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed