Funnel chest
Conditions
Interventions
Regular medication group (Group R):Group R: diclofenac potassium suppository 12.5mg-25mg anally at 8h and 32h postoperatively
ibuprofen 7.5mg/kg orally at 16h, 24h, 40h and 48h postoperatively (maximum 400mg/dose).
Drugs-on-demand group (Group D):Group D: Postoperative children with VAS score =4 or with verbal need to request ibuprofen 7.5 mg/kg (maximum 400 mg/dose) or diclofenac potassium suppositories 12.5 mg
Sponsors
Shanghai Children’s Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) ASA class I-II (2) Age 12-18 years old
Exclusion criteria
Exclusion criteria: (1) Patients with a history of gastrointestinal bleeding or perforation following application of NSAIDs; (2) Patients who are allergic to ibuprofen or diclofenac sodium and those who have developed asthma, urticaria, or anaphylaxis after taking aspirin, COX-2 inhibitors, and other NSAIDs; (3) Patients with narcotic drug dependence or opioid tolerance prior to enrollment; (4) Combined serious cardiac, hepatic and renal abnormalities (5) Patients who have used anticoagulant or antiplatelet drugs such as warfarin and clopidogrel for a long period of time (more than three months) in the past;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid consumption within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of compressions and dosage of intravenous analgesic pumps at 24 and 48 hours postoperatively;Incidence of moderate to severe pain (VAS pain score =4) at 4 postoperative time points (8h, 16h, 24h, 48h);Incidence of postoperative nausea and vomiting (PONV) within 48 hours of surgery;Use of additional analgesics and antiemetics;Use of additional analgesics and antiemetics;Days of hospitalization;Complications, including gastrointestinal bleeding, wound infection, hematoma, and nerve damage; | — |
Countries
China
Contacts
Public ContactJiang Yan
Department of Anesthesiology, Shanghai Children’s Hospital
Outcome results
None listed