Cognitive Dysfunction After Craniocerebral Injury
Conditions
Interventions
tVNS(Transcutaneous vagal nerve stimulation group ):The stimulation device provides stimulation according to normal stimulation parameters.Stimulation Frequency: 25Hz
Pulse Width: 500?microseconds
Sti
Sham stimulation group:Participants will use a sham stimulation device.
The device is programmed to stimulate only during the first 20 seconds
after 20 seconds, the device automatically turns off.
Sponsors
People's Liberation Army The General Hospital of Western Theater Command Chengdu, Sichuan
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Subjects must meet the following conditions: (1)Age between 18 and 65 years, no gender limitation, diagnosed with mild to moderate closed craniocerebral injury, injury occurred within one week, Glasgow Coma Scale (GCS) score =9. (2)HAMD and HAMA scores (depression scales) are both less than 7 points
Exclusion criteria
Exclusion criteria: Subjects will be excluded from this study if they meet any of the following criteria: 1. Neurological diseases that may lead to cognitive decline, including a history of open craniocerebral injury, intracranial infection, cerebrovascular disease, encephalitis, brain tumor, epilepsy, Parkinson's disease, Alzheimer's disease, white matter lesions, etc. 2. Metabolic diseases that may cause cognitive decline, such as anemia, thyroid dysfunction, folic acid and vitamin B12 deficiencies, etc. 3. Severe mental illnesses, such as severe depression or a history of gas poisoning. 4. History of general anesthesia within the past three months. 5. History of ear trauma, skin diseases, or other conditions that prevent wearing the stimulator. 6. Acute or severe life-threatening diseases. 7. Severe visual, hearing, or language problems that prevent completion of neuropsychological assessments. 8. Contraindications to transcutaneous vagus nerve stimulation (tVNS), such as implanted devices like cardiac pacemakers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale (MoCA-B); | — |
Secondary
| Measure | Time frame |
|---|---|
| Simple intelligent mental state Examination Scale;Galvis orientation and memory forgetting test scale;Functional activities of daily living scale;Electroencephalogram;Head Computed Tomography;Blood inflammatory factors ,Interleukin-6;Interleukin-10;Tumor Necrosis Factor-alpha; | — |
Countries
China
Contacts
Public ContactSHU HAIFENG
People's Liberation Army The General Hospital of Western Theater Command Chengdu, Sichuan
Outcome results
None listed