Hypoxic ischemic encephalopathy, HIE
Conditions
Interventions
Mild hypothermia treatment group:None
Non hypothermia treatment group:None
Sponsors
Peking University First Hospital Ningxia Women and Children’s Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital)
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: All children diagnosed with mild HIE Diagnosis criteria for mild HIE in newborns: Diagnosed as mild HIE according to the modified Sarnat criteria. The specific criteria are: ? level of consciousness: excitement, irritability; ? Autonomous activities: frequent and symmetrical; ? Autonomic nervous system function (sympathetic nervous system): dilated pupils, tachycardia, normal or weakened gastrointestinal motility; ? Primitive reflex: weak suction reflex, strong embrace reflex, weak tension neck reflex; ? Strong olfactory response; ? Tendon reflex is active; ? Neuromuscular control: normal muscle tone, normal posture, or mild distal curvature.
Exclusion criteria
Exclusion criteria: Excluding those who meet one of the following criteria: ? gestational age<35 weeks, birth weight<2000g; ? Severe congenital malformations such as complex congenital heart disease, complex neurological abnormalities, trisomy 21, and other chromosomal abnormalities; ? The newborn survived upon discharge, but was lost to follow-up after discharge.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurodevelopmental indicators of two groups during follow-up up to 6 and 12 months of age (Griffiths Developmental Assessment Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Two groups were followed up on physical development indicators (head circumference, length, weight) at 42 days, 3, 6, 9, and 12 months of age after birth;Mortality rate, presence of sepsis or not, coagulation dysfunction requiring transfusion therapy or not, thrombocytopenia;Mechanical ventilation time, duration of use of vasoactive drugs, days of parenteral nutrition;Is there a difference in the occurrence of liver injury and kidney injury; | — |
Countries
China
Contacts
Public ContactYongjia Ji
Peking University First Hospital Ningxia Women and Children’s Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital)
Outcome results
None listed