Dysbacteriosis
Conditions
Interventions
Intervention group:Take 1 bag of powder containing Lacticaseibacillus paracasei 207-27 daily, 1g per bag, with each bag containing Lacticaseibacillus paracasei 207-27 =1×10^10 CFU/g
mix with plain water or milk at a temperature not exceeding 40oC.
Control group:Take one bag of placebo (pure maltodextrin) with the same packaging daily, 1g per bag, using the same method of administration.
Sponsors
Peking University
Eligibility
Sex/Gender
All
Age
0.5 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1. Healthy infants aged 7-36 months delivered at full term meet the standards for healthy infants of their age group, and their parents can understand the requirements of the agreement and complete the baby diary as required; 2. Healthy, singleton or twin, gestational age >= 37 weeks (who), birth weight >= 2500 g, current weight is between P20 and p80 according to the percentage map of the weight of children aged 0-18; 3. The intervention group and the control group were infants fed with mixed feeding or artificial feeding; 4. Parents agree to take the recommended probiotics; 5. The infant formula does not contain probiotics, and can only contain galactooligosaccharide (GOS) < 2G/100g as prebiotics without fructooligosaccharides.
Exclusion criteria
Exclusion criteria: 1. Congenital disease or deformity; Severe prenatal and post natal diseases; Mothers with metabolic and / or chronic diseases; Probiotic allergy constitution; Infants with serious diseases, such as cardiovascular diseases, cerebrovascular, endocrine, liver, kidney and hematopoietic system or mental diseases; 2. Ingestion of other drugs that may affect the effect during the study, resulting in failure to judge the efficacy of probiotics and/or affect the judgment of results; 3. Current or past diseases, conditions, or interventions that may interfere with the study (affecting tolerance and/or growth and development), such as gastrointestinal malformations, chronic diarrhea, malabsorption syndrome, malnutrition, congenital immune deficiencies, or major surgeries; 4. Oral antibiotics or other medications or nutritional supplements containing probiotics and prebiotics (excluding infant formula) taken within 2 weeks before the intervention; 5. Special medical purpose foods in the form of non-standard formula powders, used for lactose intolerance and galactosemia; 6. Infants with potential food allergies, such as allergies to milk, soy protein, fish protein, or egg protein; 7. Participation in or having participated in other clinical studies within the 4 weeks prior to the intervention; 8. The legal guardian of the baby has mental or mental illness and does not have the language ability to sign the informed consent form; 9. The investigator can judge the reason why the infant's parents cannot meet the requirements of the study record (such as being unable to contact the investigator in an emergency, or suffering from drug and alcohol addiction).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora;sIgA;Weight;Height;Head circumference; | — |
Countries
China
Contacts
Public ContactYumei Zhang
Department of Nutrition and Food Hygiene, School of Public Health, Peking University
Outcome results
None listed