Polycystic ovarian syndrome
Conditions
Interventions
PCOS intervention group:Low carbohydrate diet
PCOS normal weight group:None
PCOS overweight and obesity group:
Healthy control group with normal weight:None
Healthy control group with overweight and obese:None
Sponsors
the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Observation section: The case group consists of unmarried women aged 18-40 years old, who meet the Rotterdam diagnostic criteria. The control group consists of healthy women with BMI matching. Intervention section: Overweight or obese PCOS patients (BMI = 24 kg/m2) aged 18-40 years who have not yet reached menopause, meet the Rotterdam diagnostic criteria. Good health condition; Thoroughly understand the nature, significance, potential benefits, inconvenience, and potential dangers of the experiment before conducting it; Understand the research procedure and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Observation section: During pregnancy/lactation period; Suffering from diabetes, hypertension, metabolic syndrome and immune system diseases; Smoking/drinking alcohol; Have taken antibiotics in the past 3 months; Regularly take proton pump inhibitors, laxatives, prebiotics/probiotic products (= 3 times a week); Gastrointestinal diseases (such as inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, etc.) and history of gastrointestinal surgery; Significant changes in dietary structure have occurred in the past three months; Acute infection has occurred in the past 2 weeks. Intervention section: Serious heart, lung, liver, kidney, nerve, mental, infection, and tumor; Pregnancy/lactation period; Suffering from diabetes, hypertension, metabolic syndrome and immune system diseases; Other diseases that cause hyperandrogenism or hyperandrogenism symptoms, such as Cushing's syndrome, non classical congenital adrenal hyperplasia (NCCAH), tumors of the ovaries or adrenal glands that secrete androgens, and drug-induced hyperandrogenism; Other diseases that can cause ovulation disorders such as functional hypothalamic amenorrhea, thyroid disease, hyperprolactinemia, and premature ovarian insufficiency (POI); Smoking/drinking alcohol; Have taken antibiotics in the past 3 months; Regularly take proton pump inhibitors, laxatives, prebiotics/probiotic products (= 3 times a week); Gastrointestinal diseases (such as inflammatory bowel disease, irritable bowel syndrome, colorectal cancer, etc.) and history of gastrointestinal surgery; Significant changes in dietary structure have occurred in the past three months; Acute infection has occurred in the past 2 weeks.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| blood glucose;Height, weight, waist circumference, hip circumference, blood pressure, body fat composition; | — |
Primary
| Measure | Time frame |
|---|---|
| basic information of patients;lipid level;Sex hormone;16S rRNA sequencing;Inflammatory factors;Clinical hyperandrogenism performance;Gynecological ultrasound; | — |
Countries
China
Contacts
Public ContactLu Yan
The First Af?liated Hospital of Soochow University
Outcome results
None listed