Dyslipidemia
Conditions
Interventions
Control group:Administer two placebo soft capsules twice daily
CoQ10 group:Administer CoQ10 soft capsules twice daily, with two capsules per administration
the intervention dose of CoQ10 is 120mg/day.
Sponsors
Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Participants aged 18-70 years who are permanent residents of Guangzhou or Foshan communities and have resided there for more than 10 years. (2) Individuals meeting at least two diagnostic criteria for primary dyslipidemia as per China's "Recommendations for Prevention and Treatment of Dyslipidemia": fasting triglyceride (TG) levels =1.7mmol/L (150mg/dL); total cholesterol (TC) levels =5.20 mmol/L (200 mg/dL); low-density lipoprotein cholesterol (LDL-C) levels =3.12 mmol/L (120 mg/dL); high-density lipoprotein cholesterol (HDL-C) levels =0.91 mmol/L (35 mg/dL). (3) Regular dietary habits, limited consumption of meals outside, and stable weight over the past three months. (4) Individuals committed to maintaining their current diet and exercise routines in the short term.
Exclusion criteria
Exclusion criteria: (1) Patients with severe dyslipidemia, specifically characterized by fasting serum total cholesterol (TC) levels =8.0mmol/L (309mg/dL) or fasting serum triglyceride (TG) levels =4.5mmol/L (395mg/dL); (2) Individuals with a medical history of cardiovascular disease or atherosclerosis, including myocardial infarction, stroke, prior coronary surgery, angiographically confirmed coronary heart disease, hyperthyroidism or hypothyroidism, cancer, liver and kidney insufficiency; (3) Subjects who are currently taking or have taken within the past six months any medications or dietary supplements that impact lipid and glucose metabolism as well as inflammation and oxidative stress. This includes lipid-lowering drugs such as statins and fibrates, health products or dietary supplements containing coenzyme Q10, anthocyanins, resveratrol etc.; (4) Pregnant women and breastfeeding mothers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cholesterol;Triglyceride;High density lipoprotein cholesterol;Low density lipoprotein cholesterol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Apolipoprotein A-?;Apolipoprotein B;Cholesterol efflux capacity;Aspartate aminotransferase;Alanine aminotransferase;?-glutamyltransferase;Total bilirubin;Fasting blood glucose;Fasting insulin;Blood pressure; | — |
Countries
China
Contacts
Public ContactWenhua Ling
Sun Yat-sen University
Outcome results
None listed