Safety and efficacy of induction and maintenance of general anesthesia with ciprofol in elderly patients undergoing hip fracture surgery: a double-blind, randomized controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400089819

Enrollment

Unknown

Registered

2024-09-18

Start date

2024-10-01

Completion date

Unknown

Last updated

2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip fracture

Interventions

ciprofol group :Induction and maintenance of general anesthesia with ciprofol

propofol group :Induction and maintenance of general anesthesia with propofol

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 65 years = 85 years (male or female not limited); 2. ASA was graded as II-III; 3. 18kg/m2 = BMI = 30kg/m2; 4. Be able to understand the procedures and methods of this study, be willing to sign the informed consent form and strictly follow the clinical research protocol to complete this study

Exclusion criteria

Exclusion criteria: 1. Patients with preoperative neurological or psychiatric disorders or communication disorders; 2. Allergic to the drugs used in this study; 3. Patients with severe arrhythmia, such as second or third degree atrioventricular block or significant bradycardia (hr<50 beats / min); 4. New York Heart Association (NYHA) cardiac function class III or IV; 5. Preoperative diagnosis was respiratory failure (PaO2 < 60mmhg); 6. Those whose blood pressure was not satisfactorily controlled (sitting systolic blood pressure = 160mmhg, and / or diastolic blood pressure = 100 mmHg in the screening period); 7. Those who participated in any clinical trial as subjects within 1 month before enrollment.

Design outcomes

Primary

Measure	Time frame
Incidence of hypotension during induction and maintenance of general anesthesia;	—

Secondary

Measure	Time frame
The incidence and frequency of hypotension during induction and maintenance of general anesthesia, as well as the incidence and frequency of severe hypotension (MAP = 55mmHg), and the difference between maximum and minimum MAP during observation.;The success rate of general anesthesia induction, the success rate of general anesthesia maintenance;Lost consciousness time, PACU dwell time, tracheal tube removal time;Adverse event incidence rate;Postoperative Recovery Quality Scale;	—

Measure

Time frame

The incidence and frequency of hypotension during induction and maintenance of general anesthesia, as well as the incidence and frequency of severe hypotension (MAP = 55mmHg), and the difference between maximum and minimum MAP during observation.;The success rate of general anesthesia induction, the success rate of general anesthesia maintenance;Lost consciousness time, PACU dwell time, tracheal tube removal time;Adverse event incidence rate;Postoperative Recovery Quality Scale;

—

Countries

China

Contacts

Public ContactDuan gongchen

Lishui People's Hospital

981225178@qq.com+86 189 5709 3030

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026