postpartum depression
Conditions
Interventions
Experimental group: dexmedetomidine was given 0.5ug/kg, and 100 ml of 0.9% normal saline was infused for 15min after delivery. After operation, PCIA was given sufentanil 1.5 ug/kg+dexmedetomidine 2 ug
control group:100 ml of 0.9% normal saline was given after delivery. After operation, PCIA was given sufentanil 1.5 ug/kg and tropisetron 4mg.
Sponsors
Jiangxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The participants were parturients who underwent elective cesarean delivery under spinal anesthesia and required postoperative patient-controlled intravenous analgesia (PCIA).Inclusion criteria were as follows: 18 years of age or older, prenatal depression (defined as a prenatal Edinburgh Postnatal Depression Scale [EPDS] score >9)
Exclusion criteria
Exclusion criteria: Exclusion criteria: Dexmedetomidine or Esketamine allergic patients, heart rate less than 50 beats /min, patients with abnormal heart conduction or rhythm, unstable history of mental illness or psychotropic substance abuse, excessive blood loss during operation, transfer to ICU, and serious diseases such as heart, lung, liver and kidney.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of positive PPD screening results at 42 days post partum ; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of positive PPD screening results at 24h and 3 days post partum and EPDS score;Adverse events at 6h, 24h and 48h postpartum.; | — |
Countries
China
Contacts
Public ContactHeguo Luo
Department of Anesthesiology, Jiangxi Provincial People's Hospital
Outcome results
None listed