Perioperative Neurocognitive Dysfunction
Conditions
Interventions
Sevoflurane group:Intraoperative maintenance by inhalation anesthesia
Propofol group:Intraoperative maintenance by intravenous anesthesia
Sponsors
West China School of Medicine and West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged 65 years or older, elective non-cardiac surgery under general anesthesia 2) Signed informed consent 3) ASA grade I-III 4) Expected anesthesia time (defined as the time from anesthesia induction to discontinuation of anesthetic drugs) greater than 60 minutes
Exclusion criteria
Exclusion criteria: 1) History of mental and nervous system diseases such as autism, attention deficit hyperactivity disorder, epilepsy, cerebral infarction, etc. 2) History of cranial surgery; 3) High risk of reflux aspiration who requires rapid sequential induction 4) Long-term use of centrally active drugs, such as nikethamide, caffeine, etc. 5) Hearing, language communication, limb movement or intellectual disabilities 6) Conflict between the EEG monitoring site and the surgical disinfection site 7) Allergy to the drugs and sensors used in the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in EEG characteristics before and after loss of consciousness;Changes in EEG characteristics associated with noxious stimulation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of postoperative delirium;The incidence of postoperative cognitive dysfunction;To analyze the relationship between characteristic changes in intraoperative EEG and the incidence of postoperative neurocognitive dysfunction;;Analysis of the relationship between characteristic changes in EEG and postoperative hospital stay;The Quality of Recovery-40 (QoR-40) scale was used to evaluate the postoperative recovery of patients on the first, second, and third days after surgery and to analyze the relationship between the recovery and characteristic changes in EEG.;The EORTC QLQ- C30 (EORTC QLQ-C30) scale was used to evaluate the patients' quality of life at 3 months, 6 months, and 1 year after surgery, and the relationship between the quality of life and the characteristic changes of intraoperative EEG was analyzed;;Isoelectric EEG (amplitude <10µV and duration =0.5secs) incidence, duration and proportion;Comparison of the intensity of noxious stimulation during the peri-anesthesia period of different types of surgery;;Effects of body temperature on brain electrical activity; | — |
Countries
China
Contacts
Public ContactZhao yuyi
West China School of Medicine and West China Hospital, Sichuan University
Outcome results
None listed