rosacea
Conditions
Interventions
1:Hydroxychloroquinone plus doxycycline
(Hydroxychloroquine Tablet 0.2g Bid + Doxycycline Capsule 0.1g Qd) for 8 weeks. During the trial, the patient was given 1 capsule + 2 tablets in the morning and
2:Doxycycline
(Doxycycline Capsule 0.1g Qd + Hydroxychloroquine Placebo 4 tablets) for 8 weeks. During the trial, the patient was given 1 capsule + 2 tablets in the morning and 2 tablets in the evenin
Sponsors
Guizhou Provincial People's Hospital (Single center research)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with severe erythema glaucoma dilatation and papular pustular rosacea (based on diagnostic criteria and scoring rules = 5 points); 2. Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Age 60 years old; 2. Pregnant and lactating women and the recent pregnancy planner; 3. Accompanied by moderate to severe liver, kidney, lung or blood and other systemic diseases; 4. Combined with nasal hypertrophy of hypertrophic rosacea patients; 5. Within 3 months of oral administration of glucocorticoids, antibiotics or Victoria A acid and so on; 6. 1 month and outside with glucocorticoid ointment or tacrolimus (pimecrolimus) or laser and other treatment; pregnant and lactating women; accompanied by moderate to severe liver, kidney, lung or blood and other diseases; 7. Consolidate the facial manifestations of other facial skin diseases or other diseases; 8. To be expected to not adhere to follow-up patients; 9. Participated in any clinical trial in January; 10. People with mental disorders; 11. Allergy to chloroquine or hydroxychloroquine or allergy to tetracycline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical examination;vital signs;Blood routine;Urine routine;liver function;Renal function;ANA;Fundus examination;Urine pregnancy tes;Rose Acne Patient Face VISIA Photo;Rose Acne Scoliosis Scale; | — |
Countries
China
Contacts
Public ContactXin Yuan
Guizhou provincial people's hospital
Outcome results
None listed