Neurological pain related diseases
Conditions
Interventions
experimental group:Double blind treatment period:
In the test group, according to the pharmacokinetics of amitriptyline tablets, amitriptyline spray was administered for 1 week, 3-4 times, tid
Open treatment period:
After completing a one week double-blind treatment, patients in the experimental group entered the open treatment phase. At the second week, subjects with visual analogue pain s
The use of amitriptyline spray will be suspended for subjects with VAS score = 3.
control group:Double blind treatment period:
The placebo control group (with the same appearance as the amitriptyline spray) received placebo treatment of external excipients, 3-4 sprays/time, tid, la
Sponsors
Pain Department of Taihe Hospital, Shiyan City
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. All patients' pain met the diagnostic criteria for neuropathic pain (i.e. DN4 >= 4). 2. When signing the informed consent form, age >= 18 years old, gender not limited; 3. During screening and baseline examination, the pain area should not exceed the range of two skin segments; 4. For adult participants, fully understand the trial content, voluntarily participate in the trial, and sign an informed consent form; 5. Agree to our department's basic treatment plan (conventional oral medication, nerve block, and radiofrequency basic treatment).
Exclusion criteria
Exclusion criteria: 1. The patient's pain components are complex and do not belong to or completely belong to neuropathic pain patients. 2. Patients who need to transfer due to underlying diseases are no longer suitable for continuing the trial; 3. The patient has mental and psychological disorders and is expected to be unable to cooperate with the experimenter. 4. Individuals with skin infections or potential infection risks at the affected area. 5. Subjects who are pregnant, breastfeeding, or planning to conceive; 6. Asthma and other acute respiratory patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Pain Rating Scale;Infrared thermal imaging;Somatosensory evoked action potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| McGill Pain Questionnaire; | — |
Countries
China
Contacts
Public ContactLai Jinyu
shiyan taihe hospital
Outcome results
None listed