age-related macular degeneration
Conditions
Interventions
RMD group:None
non-RMD group:None
Sponsors
the First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosed with RMD will be included in the RMD group, at least one eye met both of the above criteria and the reticular lesions covered more than 1/2 of the retina above the macular area or more than 1/3 of the retinal area and were dispersed in the papillary temporal and nasal retinas; 2) Early and part of intermediate AMD subjects without RPD will be included in the non-RMD group, include a combination of multiple small drusen, few intermediate drusen (63–124 µm in diameter), or mild RPE abnormalities (AREDS category 2); Numerous intermediate drusen or/and at least one large druse (=125 µm in diameter) (part criteria of AREDS category 3). 3) Considering the diagnostic criteria for AMD, subjects over the age of 50 years will be included. AMD will be diagnosed using criteria developed by The Age-Related Eye Disease Study Research Group (AREDS) in 2013. The diagnosis of RMD are as follows: 1) Infrared imaging of the fundus revealed reticular low-reflection spots on the background with relatively high reflection. 2) Spectral domain-OCT images showed the presence of clusters of granular hyperreflective deposits located above the RPE, which compressed the ellipsoid reflection zone with wavy uplift or interruption of continuity or breached the outer membrane boundary to the outer nuclear layer. Only one eye per participant will be eligible for the study. If both eyes are eligible for the study, the eye with a thinner outer nuclear layer (ONL) in the fovea will be recruited.
Exclusion criteria
Exclusion criteria: 1) advanced stage of AMD will be excluded, considering that advanced-AMD will be one of the outcome events in this study. 2) Stargardt disease, Best disease and other known RPE–photoreceptor injury diseases. 3) Refractive media opacification such as severe vitreous opacity and cataract may affect retinal light perception during EOG examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EOG parameter; | — |
Secondary
| Measure | Time frame |
|---|---|
| neural retinal thickness;Neural retinal blood flow density; | — |
Countries
China
Contacts
Public ContactCheng Hao
the First Affiliated Hospital, Guangzhou Medical University
Outcome results
None listed