Diaphragmatic weakness in elderly patients undergoing lower extremity fracture surgery under intraoperative sedation
Conditions
Interventions
Remazolam sedation group:The initial dose of remazolam group is 0.075 mg/kg and maintained by 0.5mg/kg*h for 5 minutes. When the patient did not reach the MOAA/S score of 3, the infusion rate of remaz
Dexmedetomidine sedation group:A loading dose of 1µg/kg of dexmedetomidine was given and the infusion was completed within 10 minutes. The infusion rate was maintained by titration method with the ini
Sponsors
The First Affiliated Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age =65 years old; 2.ASA physical status I-III; 3.surgical duration <120min; 4.Elective orthopedic surgery of knee joint and below knee joint;
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria:Emergency surgery and/or intraoperative massive bleeding; 2.History of anaesthesia related drug allergy; 3.Severe heart, lung, liver, kidney, nervous, blood system diseases or muscle related diseases; 4.Use drugs known to affect neuromuscular function or cause drowsiness within 2 weeks; 5.Mental illness; 6.Patients enrolled in other clinical trials within 6 months; 7.Anesthesia failure due to puncture failure; 8.Preoperative application of anticoagulants; 9.The patient refused;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diaphragm thickening fraction during tidal breat; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diaphragm thickness during tidal breathing;Diaphragm excursion during tidal breathing;Incidence of diaphragm weakness;Diaphragm thickening fraction during maximal inspiration;Diaphragm thickeness during maximal inspiration;Diaphragm excursion during maximal inspiration;Diaphragm thickness during tidal breathing; | — |
Countries
China
Contacts
Public ContactJiehao Sun
The First Affiliated Hospital, Wenzhou Medical University
Outcome results
None listed