Chronic kidney disease
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. adults (age = 18 years), 2. MHD = three months, 3. hemodialysis three sessions per week, 4. ability to walk independently, 5. Normal cognitive ability, ability to understand exercise instruction, and 6. ability to read Chinese; 7. No acute complications (such as acute infection, unstable angina, acute myocardial infarction, stroke, recent fractures, etc.).
Exclusion criteria
Exclusion criteria: 1. exercise regularly (i.e., >150 minutes per week of aerobic exercise or structured resistance exercise > one session per week), 2. contraindications to exercise training (e.g., musculoskeletal factors and neurological conditions), 3. Individuals with hemodynamic instability: SBP = 180 mmHg or DBP = 105 mmHg before dialysis, rest heart rate = 120 beats per minute, symptomatic heart failure, severe arrhythmia, weight gain during dialysis interval = 4kg; 4. high risk of BFR implementation: coagulation or presence of signs of thrombophlebitis, diagnosis of peripheral vascular disease in the lower limbs, significant edema in both lower limbs, skin damage of any low limb, etc., 5. had a single-pool Kt/V (spKt/V) value of < 1.2. 6. with lower limb deep vein catheterization or lower limb arteriovenous fistula.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RNA-seq data;6-minute walking test;Dialysis adequacy ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Handgrip strength (HGS);30-second sit-to-stand-to-sit test (STS30);Time up-and-go test (tug);Health-related quality of life;blood pressure;heart rate; | — |
Countries
China
Contacts
Public ContactHuang Ying
The First Affiliated Hospital of Soochow University
Outcome results
None listed