None
Conditions
Interventions
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
20 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. 200 patients who underwent elective laparoscopic surgery in our hospital, women aged 20-59 years old, were selected; 2. American Society of Anesthesiologists (ASA) class I-III; hepatic function Child grade A; 3 Body mass index (BMI) 18-28; 4 Proposed to perform gynecological systemic surgery under general anesthesia laparoscopy, with an operating time of 60-120 minutes; 5 Can communicate effectively, can complete postoperative pain assessment after training, agree and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1 Serious cardiovascular diseases, such as uncontrolled hypertension and diabetes mellitus, serious respiratory diseases, and serious liver and kidney function abnormalities; 2 History of chronic pain, history of mental illness, long-term smoking, alcoholism; 3. History of allergy to fentanyl analogs or long-term use of analgesics; 4 Pregnant and lactating women; 5 Taking hepatic enzyme inducers, inhibitors, or foods that induce/inhibit hepatic enzyme expression within 1 month before surgery; 6, Tricyclic antidepressants, monoamine oxidase inhibitors within 2 weeks before surgery; 7, Other conditions that the investigator considers inappropriate for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| drug half-life (t 1/2); | — |
Secondary
| Measure | Time frame |
|---|---|
| blood concentration; | — |
Countries
China
Contacts
Public ContactXiaoyong Wei
Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed