Acute Respiratory Distress Syndrome
Conditions
Interventions
Experimental group:None
Control group:None
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Patients with invasive mechanical ventilation who meet ARDS ESICM criteria; (2) Meeting one of the diagnostic criteria for RVD: tricuspid valve contractile displacement (TAPSE) <17 mm, right ventricular systolic wave velocity (S ') <9.5 cm/s, right ventricular area change fraction (RVFAC) <35%, right cardiac ejection fraction <45%; (3) Within 3 days after diagnosis of ARDS; (4) All patients received deep sedation; (5) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Under 18 years old and over 85 years old; (2) Hemodynamic instability (systolic blood pressure 30mmHg), or patients with active bleeding; (3) Pregnancy; (4) Patients who have undergone bone marrow transplantation or lung transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| End-expiratory lung volume, EELV;Respiratory system compliance, Crs;Intrathoracic blood volume index, ITBI;Extravascular pulmonary water index, EVLWI;Pulmonary vascular permeability index, PVPI;Right atrial pressure, RAP;Mean pulmonary artery pressure, MPAP;Pulmonary wedge pressure, PAWP;Systemic vascular resistance index, SVRI;Pulmonary vascular resistance index, PVRI;Right ventricular function index, RVSWI;Effective Elastance, Ea;End-systolic elastance/Effective Elastance, Ees/Ea;Transpulmonary gradient, TPG; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak pressure, Ppeak;Plateau pressure, Pplat;Driving pressure, PD;ratio of dead space to tidal volume, Vd/Vt;Ventilation ratio, VR;Potential of hydrogen, Ph;Arterial oxygen pressure, PaO2;Arterial carbon dioxide pressure, PaCO2;Arterial oxygen pressure/Arterial carbon dioxide pressure, PaO2/FiO2;oxygen saturation in arterial blood, SaO2;Bicarbonate concentration, HCO3-;Arterial blood lactic acid, Lac;Cardiac index, CI;Stroke volume index, SVI;Global Ejection Fractions, GEF;Cardiac systolic function index, CFI;Global end-diastolic volume index, GEDI;Stroke variation rate, SVV;Pulse pressure variation, PVV;Central vein pressure, CVP;Mean arterial pressure, MAP;Heart rate, HR;Central vein oxygen saturation, ScvO2;Left ventricular function index, LVSWI; | — |
Countries
China
Contacts
Public ContactXuesong Liu
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed