hypertension
Conditions
Interventions
Control group:The control group receives traditional medication treatment and health education.
Diet and exercises group:In addition to receiving traditional medication and health education, the diet and exercises group also receives balanced dietary guidance and exercises.
Diet, probiotics, and exercises group:In addition to receiving traditional medication treatment and health education, the diet, probiotics, and exercises group also receives balanced dietary guidance,
Sponsors
School of Public Health, Shandong University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of primary hypertension. The patient has a systolic blood pressure of = 125 mmHg and/or diastolic blood pressure of = 75 mmHg in the clinic three times on different days without using antihypertensive drugs. 2. Age: 30 to 70 years old. 3. Willing to participate in the study and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Secondary hypertension; 2. Previous history of cardiovascular diseases, including angina, myocardial infarction, heart failure, acute cardiovascular events (such as acute coronary syndrome, coronary artery revascularization surgery, stroke) in the previous year, peripheral arterial disease, ventricular arrhythmias, atrial fibrillation, hypertrophic cardiomyopathy, aortic aneurysm diameter = 5.5 cm, or history of aortic aneurysm surgery; 3. Cirrhosis, liver failure, renal failure, chronic obstructive pulmonary disease, musculoskeletal disease, any gastrointestinal disease; 4; Participants participated in other clinical trials related to the treatment of hypertension in the past year; 5. Participants changed their antihypertensive medication three months prior to inclusion in the study; 6. Active malignant tumors or a history of malignant tumors within the past 5 years; 7. Participants are unable to follow recommended diets (due to religious reasons, swallowing disorders, etc.); 8. Restrict physical activities or participate in regular exercise and training; 9. Participants habitually consume more grains and supplement with probiotics; 10. Allergies to dietary interventions and food ingredients; 11. Immunodeficiency or HIV positive status; 12. Mental illnesses, including schizophrenia, bipolar disorder, eating disorders, and depression; 13. Any serious comorbidities with a life expectancy of less than 24 months; 14. Excessive drinking or drug abuse; 15. History of organ transplantation; 16. Currently using weight loss pills; 17. Pregnancy or planned pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;Waist circumference;Body composition;Ultrasound;Gut microbiota sequencing;Blood parameters;Urine parameters; | — |
Countries
China
Contacts
Public ContactMin Zhao
Department of Nutrition and Food Hygiene, School of Public Health, Shandong University
Outcome results
None listed