Thin endometrium
Conditions
Interventions
Fresh embryo transfer:None
Freeze-all:None
Sponsors
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Women aged 20 to 50 years; 2.In an IVF cycle, if the endometrial thickness is diagnosed as thin, defined as an endometrial thickness < 8 mm measured via ultrasound on the HCG trigger day, the endometrial thickness is determined as the maximum distance from one interface between the endometrium and myometrium to the other in the sagittal plane of the uterus. The endometrial thickness on the HCG day is usually used to decide whether to proceed with a fresh embryo transfer. To minimize error, repeat measurements are taken and averaged; 3.The patient underwent at least one subsequent embryo transfer (either fresh or frozen) after egg retrieval in the IVF cycle.
Exclusion criteria
Exclusion criteria: The study excluded IVF cycles involving: (1) Pre-implantation genetic testing or diagnosis; (2) The use of frozen oocytes/sperm; (3) Donor oocyte cycles; (4) In vitro maturation cycles; (5) There are cycles with clear indications for canceling fresh embryo transfer, including: ?Abnormalities in the uterine cavity or adnexa, such as endometrial structural disorders, polyps, adenomyosis, endometriosis, hydrosalpinx, or uterine diverticulum; ?Elevated progesterone on the trigger day (defined as > 1.5 ng/ml); ?Risk of severe ovarian hyperstimulation syndrome (OHSS) (defined as = 18 oocytes retrieved); ?Cycles using luteal phase stimulation, high progesterone stimulation, or clomiphene stimulation protocols. (6) Cycles where no oocytes were retrieved, no 2PN zygotes were obtained, or no viable embryos were available on day three post-retrieval were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate after first embryo transfer;Cumulative live birth rate per patient;Multiple live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age at the oocyte retrieval (years);Body mass index(kg/m2);Duration of infertility (years);Type of infertility (Primary/Secondary);Antral follicle count;number of previous IVF cycles;History of intrauterine surgery;History of uterine adhesions;History of polycystic ovarian syndrome;Male age at the oocyte retrieval (years);Male factor infertility;Controlled ovarian stimulation protocol;Total gonadotrophin (IU/ml);Days of controlled ovarian stimulation;Endometrial thickness on day of hCG trigger (mm);Estradiol on day of hCG trigger (pg/ml);Progesterone on day of hCG trigger (ng/ml);No. of oocytes retrieved;Insemination method (IVF or ICSI);No. of 2PN zygotes;No. of good-quality embryos on day 3 after oocyte retrieval;Biochemical pregnancy rate;Clinical pregnancy rate ;Miscarriage rate;Gestational age per baby;Birth weight per baby;Preterm birth rate;Low birth weight rate per baby;High birth weight per baby;Small for gestational age rate;Large for gestational age rate;multiple pregnancy rate; | — |
Countries
China
Contacts
Public ContactZhengao Sun
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Outcome results
None listed