premature ovarian insufficiency
Conditions
Interventions
Healthy control group:None
POI group :None
Sponsors
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to 39 Years
Inclusion criteria
Inclusion criteria: POI: Meeting the POI diagnostic criteria proposed in 2016 by ESHER: age25IU/L on two occasions >4 weeks apart. Control group: Select 50 healthy female volunteers who match the age, height, and weight of the POI group as the control group. Normal menstruation, sinus rhythm, no hypertension, hyperlipidemia and diabetes, and normal routine transthoracic echocardiography.
Exclusion criteria
Exclusion criteria: POI: ? age>40 years old; ? prior HRT; ? severe cardiovascular disease,including congenital cardiovascular disease, coronary heart disease, cardiomyopathy, severe arrhythmia, heart failure, pericardial disease; ? hypertension, diabetes, blood system disease, autoimmune system disease,or history of radiotherapy or chemotherapy; and ? poor image quality. Control group: Routine transthoracic echocardiography indicates abnormalities or poor image quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| subendomyocardial global longitudinal strain ;mid-layer myocardial global longitudinal strain;subepimyocardial global longitudinal strain;subendomyocardial global circumferential strain ;mid-layer myocardial global circumferential strain;subepimyocardial global circumferential strain; | — |
Secondary
| Measure | Time frame |
|---|---|
| elastic modulus; | — |
Countries
China
Contacts
Public ContactLi-xue Yin
Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital
Outcome results
None listed