0-3 years Small for gestational Age (SGA)
Conditions
Interventions
SGA Group and Non-SGA Group (Stage 1):NONE
Non-SGA Group (Phase 2):NONE
SGA Group (Phase 2):NONE
Sponsors
West China Second Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: The first stage: 1. Live newborns (single or multiple) born within a specified period of time (within 2 months); 2. Informed consent has been signed by the parent, responsible parent or legal guardian. The second stage: 1.SGA group: All infants and young children identified as SGA in the first stage were included; 2. Non-sga group: Infants with normal growth indicators such as body length, body weight and head circumference were included in the non-SGA group; 3. Parents or legal guardians have signed informed consent.
Exclusion criteria
Exclusion criteria: The first stage: 1. Gestational age can not be obtained through the last menstrual or prenatal B-ultrasound examination; 2. death at birth; 3. Unable to gain weight within 24 hours due to severe complications at birth; 4. Diseases affecting physical measurement indicators at birth, such as hydrocephalus, limb deformity, abnormal appearance, abnormal shape, fetal edema, etc.; 5. Failure of the parent or legal guardian to comply with the trial protocol; 6. Patients deemed unsuitable for clinical study by the investigator. The second stage: 1. The parent or legal guardian is unable to comply with the trial procedure; 2. Patients deemed unsuitable for clinical study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of SGA in China;Physical growth parameters of Chinese SGA within 3 years (without special drug intervention); | — |
Secondary
| Measure | Time frame |
|---|---|
| Birth weight, length and head circumference of Chinese newborns;Influencing factors of SGA occurrence;The optimal catch-up growth pattern of different types of SGA (by weight, length or two Both judge);Changes of growth hormone-insulin-like growth factor axis in SGA and non-SGA groups ;Incidence and risk causes of short stature at age 3 in SGA and non-SGA groups ;Growth and development regularity of SGA and non-SGA groups, incidence of short stature at three years of age Correlation of insulin-like growth factor in cord blood;Differences in neurodevelopmental outcomes (motor, cognitive, sensory, psychobehavioral, functional status) between different types of SGA and non-SGA groups; | — |
Countries
China
Contacts
Public ContactMao Meng
West China Second Hospital of Sichuan University
Outcome results
None listed