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Effect of combined hypertonic therapy on cerebral reperfusion edema after intravascular thrombectomy in ischemic stroke: a multicenter, prospective, randomized, open-label, endpoint blind study

Effect of combined hypertonic therapy on cerebral reperfusion edema after intravascular thrombectomy in ischemic stroke: a multicenter, prospective, randomized, open-label, endpoint blind study - CHEAMT Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089582
Enrollment
Unknown
Registered
2024-09-11
Start date
2024-09-15
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

320-320.54

Interventions

control group:Isotonic saline was given immediately after surgery
experimental group:The experimental group was given continuous drops of 3% hypertonic saline immediately after surgery, and the target monitoring blood sodium concentration was maintained at 150-160mo

Sponsors

The First Hospital of Yulin
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) All cases were in line with the diagnostic points and criteria of ischemic stroke and were confirmed by brain CT and/or MRI; 2) Patients with onset age 18-80 years old who visited the clinic within 24 hours had precirculation cerebral infarction for the first time, met the evaluation requirements of emergency thrombectomy guidelines, and successfully achieved the mTICI classification: Grade 3 recanalization.

Exclusion criteria

Exclusion criteria: 1) Transient ischemic attack; 2) Cerebral infarction secondary to other intracranial diseases such as brain tumors; 3) Pregnant or lactating women; 4) Life expectancy is less than 6 months, or due to mental illness, cognitive or emotional disorders, unable to complete the study as required; 5) Immediate postoperative CT/MRI evidence of intracranial hemorrhage (according to Heidelberg intracranial hemorrhage classification 1c and above); 6) Patients with severe cardiac, liver and renal insufficiency; 7) Refusal to sign informed consent; 8) Other conditions that clinicians believe should be excluded.

Design outcomes

Primary

MeasureTime frame
MRI-DWI;

Countries

China

Contacts

Public ContactXingshun Ma

The First Hospital of Yulin

51687040@qq.com+86 189 9227 5136

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026