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Comparison of the euploidy rate of embryos fertilized by sperm selected using microfluidics and gradient density centrifugation in patients with recurrent spontaneous abortion: a randomized double-blind sibling egg control trial

Comparison of the euploidy rate of embryos fertilized by sperm selected using microfluidics and gradient density centrifugation in patients with recurrent spontaneous abortion: a randomized double-blind sibling egg control trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089581
Enrollment
Unknown
Registered
2024-09-11
Start date
2024-10-01
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

microfluidic:Preparing sperm by microfluidic devices
gradient contrifugation:Preparing sperm by gradient contrifugation

Sponsors

First Affiliated Hospital of Kunming Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 43 Years

Inclusion criteria

Inclusion criteria: 1. Autologous sperm and autologous oocyte cycle; 2. PGT-A (Preimplantation Genetic Testing for Aneuploidies) cycle; 3. Female age ranging from 20 to 43 years old, male age = 20 years old; 4. Diagnosis of recurrent spontaneous abortion.

Exclusion criteria

Exclusion criteria: 1. severe oligospermia and asthenospermia; 2. testicular sperm and frozen-thawed sperm; 3. The volume of semen on the day of egg retrieval is less than 2mL; 4. Sperm concentration on the day of egg retrieval is less than 5x10^6/mL; 5. After egg retrieval, there are less than 6 MII eggs.

Design outcomes

Primary

MeasureTime frame
Euploidy rate per MII oocyte;—

Secondary

MeasureTime frame
Euploidy rate per tested blastocyst;High-quality embryo rate;Blastocyst formation rate;fertilization rate;sperm recovery rate;PR after preparation;—

Countries

China

Contacts

Public ContactShuhua Zhao

First Affiliated Hospital of Kunming Medical University

kmshh1982@126.com+86 138 8810 1931

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026