Epidural labor analgesia
Conditions
Interventions
Experimental group:Esketamine (0.6mg/ml) + ropivacaine (0.08%) for epidural labor analgesia
Control group A:Sufentanil (3ug/ml) + ropivacaine (0.08%) for epidural labor analgesia
Control group B:Ropivacaine (0.08%) was used for epidural labor analgesia
Sponsors
Longyan First Hospital of Fujian Province
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1: full-term primipara, single fetus, head position, age 18-40 years old, and willing to perform labor analgesia; 2:37-42 weeks of pregnancy, ASA I or II grade; 3: No vaginal delivery contraindications after prenatal examinations such as obstetrics and ultrasound. 4: There is a need for epidural labor analgesia
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1: parturient women, pathological obstetric diseases; 2: Esketamine, sufentanil, ropivacaine drug allergy; 3: For patients with long-term use of analgesics, opioid analgesics are used during childbirth before epidural analgesia; 4: Abnormal coagulation function, abnormal liver and kidney function or accompanied by high blood pressure or diabetes; 5: Poor compliance, midcourse vaginal delivery cesarean section.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPDS score and BSES score;Cortisol, interleukin-6, C-reactive protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR, BP, SPO2, FHR, Rmsay sedation score, Bromage score, NRS score, upper sensory block plane,Analgesia onset time;Apgar scoregas analysis of umbilical artery in newborn;The number of analgesic pump compressions, the total amount of ropivacaine, the duration of the first stage of labor, the duration of the second stage of labor, and the satisfaction of maternal analgesia; | — |
Countries
China
Contacts
Public ContactXiaoqing Lin
Longyan First Hospital of Fujian Province
Outcome results
None listed