Cerebral infarction
Conditions
Interventions
The study group:During the acute phase of cerebral infarction (within 14 days of onset), according to the pupillary ultrasound measurement method and testing plan developed by our research institute,
Control:Receive routine diagnosis and treatment
Sponsors
The First Affiliated Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old; 2. Meets the diagnostic criteria for large area cerebral infarction in the anterior circulation (infarction in the middle cerebral artery supply area = 2/3, with or without infarction in the anterior cerebral artery/posterior cerebral artery supply area); 3. The onset time is = 24 hours. 4. Able to sign informed consent forms or obtain family consent.
Exclusion criteria
Exclusion criteria: 1. Any clinically detectable pupil dysfunction or visual field defect; 2. Prior to this onset, there were abnormalities in the optic or oculomotor nerves and their nuclei; 3. Any eye disease (such as glaucoma, cataract, macular degeneration or diabetes retinopathy); 4. Patients with neurological diseases that may cause optic neuropathy or optic atrophy (such as multiple sclerosis, clinically isolated syndrome, optic neuromyelitis spectrum disorder, chronic recurrent inflammatory optic neuropathy, or Leber hereditary optic neuropathy), Or any autoimmune or systemic disease that may have an impact on the autonomic nervous system (such as Guillain Barre syndrome, viral or borderline encephalitis, multiple system atrophy, sarcoidosis, and systemic lupus erythematosus); 5. Patients who have previously undergone any type of ophthalmic surgery or laser treatment; 6. Patients who take local or systemic medications that may affect pupil function before onset. 7. Patients with other neurological or severe systemic diseases; 8. Refusal to participate in this study or inability to cooperate in completing follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Static (indoor natural light):Pupil size, i.e. maximum and minimum aperture (mm);Static (indoor natural light):The difference in pupil diameter on both side;Dynamic (when the pupil is illuminated by light): Latency of light reflection (s);Dynamic (when the pupil is illuminated by light): The speed of pupil contraction and re dilation (mm/s);Percentage change in pupil diameter; | — |
Countries
China
Contacts
Public ContactWang Zhiqiang
The Department of Neurology, the First Affiliated Hospital of Fujian Medical University
Outcome results
None listed