Knee osteoarthritis
Conditions
Interventions
control group:Ondansetron 8mg (4ml: 8mg) was slowly administered intravenously 30 minutes before the end of the procedure (2 minutes).
experimental group:Aprepitant 130mg (18ml:130mg) was slowly administered intravenously 30 minutes before the end of the procedure (2 minutes).
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with severe knee osteoarthritis are eligible for TKA surgery; 2. No cognitive dysfunction or psychiatric history before surgery; 3. Age < 80, no gender limitation; 4. Body weight < 100 kg; 5. ASA score was I-II; 6. Clearly understand and voluntarily participate in the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic or intolerant to the experimental drug; 2. Patients with concurrent hepatic and renal insufficiency; 3. Patients with severe intestinal peristalsis; 4. Patients with concurrent arrhythmias, such as atrioventricular block and ventricular arrhythmias 5. Persons with mental disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV at 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence and severity of PONV at 12h, 36h and 48h after operation;VAS score;Time of first postoperative defecation;First time out of bed;Postoperative appetite score;Incidence of treatment-related adverse reactions of grade 1-2 and above; | — |
Countries
China
Contacts
Public ContactFan Lixia
Qilu Hospital of Shandong University
Outcome results
None listed