Periodontitis
Conditions
Interventions
Gold Standard:Loss of attachment on the adjacent surfaces of two or more noncontiguous teeth or
Loss of attachment of =3 mm on the (lingual) surfaces of =2 teeth with >3 mm of periodontal pockets
Index test:ELISA
Biomarkers: MMP-8, MMP-9, IL-1ß, IL-1, Hb
Sponsors
School of Stomatology, The Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Age greater than 18 years old (including 18 years old), gender is not limited; 2) Retention of at least 20 natural teeth in the mouth; 3) Periodontal tissues were intact without recession, no bleeding from probing, no redness or swelling, and the patient was asymptomatic with no loss of attachment or bone loss; 4) Probing the sulcus floor of 6 sites (proximal mesiobuccal, buccal, distal mesiobuccal, proximal mesiolingual, lingual, distal mesiolingual) of all the teeth with a standardized probe with a pressure of approx. 0.25 N. The probing bleeding sites were <10%, and probe depth =3 mm; 5) No periodontal treatment in the last three months; 6) not taking antibiotics in the last one month; 7) Being conscious, able to answer correctly, able to cooperate with the study, participating voluntarily and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Acute foci of infection in the mouth, such as acute pulpitis, apical periodontitis, periodontal abscess, and interstitial infection; 2) Women with recent fever, allergies, alcoholism, pregnancy or lactation; 3) Salivary gland diseases such as salivary gland stones, salivary gland inflammation or salivary gland tumors; 4) Patients with dry mouth; 5) Patients with HIV or active HBV or HCV infection; 6) Patients on immunosuppressive therapy; 7) Patients with bleeding disorders; 8) Patients with malignant tumors; 9) Chronic renal failure or cirrhosis; 10) Taking drugs that affect bone metabolism or gums; 11) Other patients deemed unsuitable for enrollment by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Attachment Loss;Accuracy;Sensitivity;Specificity;Positive predicative value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding On Probing; | — |
Countries
China
Contacts
Public ContactLina Niu
School of Stomatology, The Fourth Military Medical University
Outcome results
None listed