Effect of Intraoperative Combined Dexmedetomidine Pump Injection on Postoperative Delirium in Elderly Patients Undergoing Lower Extremity Orthopedic Surgery Under Neuraxial Anesthesia: A Prospective Single-center Controlled Clinical Trial

Effect of Intraoperative Combined Dexmedetomidine Pump Injection on Postoperative Delirium in Elderly Patients Undergoing Lower Extremity Orthopedic Surgery Under Neuraxial Anesthesia: A Prospective Single-center Controlled Clinical Trial - Effect of intraoperative combined dexmedetomidine pump injection on postoperative delirium in elderly patients undergoing lower extremity orthopedic surgery under neuraxial anesthesia

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400089461

Enrollment

Unknown

Registered

2024-09-09

Start date

2022-11-01

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower limb fractures

Interventions

Experimental group:Neuraxial anesthesia combined with dexmedetomidine continuous pumping.

Control group:Neuraxial anesthesia combined with blank placebo (0.9% NS) continuous pumping.

Eligibility

Sex/Gender

All

Age

65 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age 65~90 years old; 2. No contraindications to lower limb orthopedic surgery; 3. No contraindication to neuraxial anesthesia; 4. ASA Grading II.-III; 5. The estimated duration of the operation is >1h.

Exclusion criteria

Exclusion criteria: 1. Coagulation dysfunction or hematologic diseases; 2. Cardiopulmonary function is unable to tolerate surgery or anesthesia; 3. History of preoperative epilepsy or dementia; 4. Arrhythmia or dysfunction of the electrical conduction system of the heart.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium;	—

Secondary

Measure	Time frame
POD duration and severity;VAS pain score at 6h/12h/24h/48h postoperatively;Incidence of postoperative 3d PONV;Number of PCAs and total usage;	—

Countries

China

Contacts

Public ContactGong Shangjun

People's hospital of lujiang county,anhui province

1135872500@qq.com+86 157 5538 6296

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026