Esophageal Cancer
Conditions
Interventions
Sponsors
Gaozhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Retrospective Part: 1. Patients who visited the study department between January 1, 2022, and August 29, 2024; 2. Patients with recurrent or distant metastatic esophageal cancer confirmed by pathology or clinically (AJCC 8th Edition); 3. Inoperable locally advanced patients who cannot or are unwilling to accept definitive treatment (including definitive chemoradiotherapy or definitive radiotherapy, etc.) may also be considered for enrollment; 4. Patients who have progressed or recurred after neoadjuvant or adjuvant therapy may also be considered for enrollment; 5. Age = 18 years old; 6. Complete medical records. Prospective Part: 1. Patients with recurrent or distant metastatic squamous cell carcinoma of the esophagus confirmed by pathology or clinically (AJCC 8th Edition); 2. Age = 18 years old; 3. First-line patients who have not received systemic treatment or are in the process of first-line systemic treatment containing tislelizumab, with no less than four courses of first-line treatment, and continue to receive tislelizumab in the second-line after progression; 4. Second-line patients must have received at least four courses of PD-1/PD-L1 other than tislelizumab during first-line treatment, and patients with PD within 6 months of first-line treatment are excluded; 5. Intend to receive tislelizumab treatment; 6. Good compliance and willingness to accept long-term follow-up.
Exclusion criteria
Exclusion criteria: 1. Participating simultaneously in another clinical study that is blinded; 2. Having other active malignant tumors or multiple primary cancers; 3. Pregnant or lactating women, or men and women planning to conceive during the study period; 4. Other situations deemed unsuitable for inclusion in the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;=3 TRAE;irAE; | — |
Countries
China
Contacts
Public ContactWen Zunbei
Gaozhou People's Hospital
Outcome results
None listed