Hypopharyngeal carcinoma
Conditions
Interventions
Standard surgical margin group:The shortest surgical margin around the primary lesion in hypopharyngeal carcinoma surgery is = 5 mm and < 10 mm.
Extended surgical margin group:The shortest surgical margin around the primary lesion in hypopharyngeal carcinoma surgery is = 10 mm.
Sponsors
Eye & ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Have signed the research informed consent form and voluntarily joined this clinical study; 2. Age: 20-80 years old; 3. Pathologically diagnosed with hypopharyngeal carcinoma; 4. Patients with surgically resectable T1-T2 hypopharyngeal carcinoma; 5. Preoperatively acceptable to receive neoadjuvant therapy (chemotherapy, targeted therapy, immunotherapy, and/or radiation therapy) achieving partial remission, but not achieving complete remission (CR).
Exclusion criteria
Exclusion criteria: 1. History of concurrent malignant tumors in other locations (except for papillary thyroid cancer or other early tumors with good treatment results); 2. Preoperative radical treatment for recurrent patients; 3. Poor compliance, unwilling to cooperate with the treatment, or resistant to changes in the treatment plan; 4. Lack of complete clinical information and complete follow-up; 5. Other reasons unsuitable for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease-free survival;Cancer-specific survival;Overall survival;Treatment of hypopharyngeal carcinoma surgery and skin flap reconstruction;Larynx preservation rate after operation;Preoperative treatment;Progression-free survival;Postoperative quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of swallowing function postoperatively;Degree of speech function postoperatively;Postoperation pain;Postoperation treatment;Treatment cost; | — |
Countries
China
Contacts
Public ContactChengzhi Xu
Eye & ENT Hospital of Fudan University
Outcome results
None listed