Respiratory depression
Conditions
Interventions
Group A:Anesthesia induction: alfentanil 8ug/kg+ propofol 1.5mg/kg
Maintenance of anesthesia: continuous infusion of propofol 4-12mg/kg/h+alfentanil 0.25ug/kg/min.
Group R:Anesthesia induction: remifentanil 0.4ug/kg+ propofol 1.5 mg/kg
Maintenance of anesthesia: continuous infusion of propofol 4-12mg/kg/h+remifentanil 0.05ug/kg/min.
Sponsors
The First Affiliated Hospital of Nanhua University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Subjects undergoing painless fiberoptic bronchoscopy under general anesthesia; (2) 65-85 years old, male or female; (3) American Society of Anesthesiologists (ASA) grades II-III; (4)18kg/m2=BMI= 28kg/m2; (5) Voluntary participation in this study and signing of informed consent.
Exclusion criteria
Exclusion criteria: (1) Have a history of drug allergy related to the test; (2) Long-term use of analgesics or psychotropic drugs, and alcohol abusers; (3) Severe abnormality of liver and kidney function before operation; (4) Have a history of recovery from abnormal operation anesthesia; (5) There was uncontrolled hypertension in the past, or the systolic blood pressure > 180mmHg, or the diastolic blood pressure >110mmHg, or the preoperative heart rate < 60 beats/min; (6) Those who have bronchial asthma recently or are suffering from massive hemoptysis; (7) Severe stenosis of the main airway; (8) myasthenia gravis; (9) Patients with acute exacerbation of chronic obstructive pulmonary disease; (10) Suffering from esophageal reflux disease; (11) Predicted as a difficult airway; (12) Having participated in other drug trials within three months or unable to communicate effectively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| low blood pressure;bradycardia;success rate of the first fiberoptic bronchoscopy;bronchoscopy score;endoscopist satisfaction;patients' willingness to receive treatment again;drug dosage;postoperative awakening time;time out of the operating room;vital signs; | — |
Countries
China
Contacts
Public ContactXiaoling Hu
The First Affiliated Hospital of Nanhua University
Outcome results
None listed