chronic postsurgical pain
Conditions
Interventions
Experimental group:Postoperative analgesic use: bupivacaine liposomal ultrasound-guided T4-T9 multipoint intercostal nerve block + PCIA
Control group:Postoperative analgesia: PCIA alone
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) patients undergoing elective three-port thoracoscopic thoracic surgery (including lobectomy, segmental resection, and wedge resection of pulmonary nodules), (2) aged 18-75 years, and (3) American Society of Anaesthesiologists (ASA) classification I-III.
Exclusion criteria
Exclusion criteria: (1) emergency trauma surgery, (2) New York Heart Function Score (NYHA) 3-4, (3) conduction block, (4) unstable coronary artery disease, (5) gastric ulcers or gastric haemorrhage, (6) a body mass index (BMI) of 37 kg/m2, (7) diabetes mellitus treated with insulin, (8) renal insufficiency (serum creatinine value above the normal threshold), (9) hepatic insufficiency (alanine aminotransferase or aspartate aminotransferase more than twice normal), (10) coagulation disorders (prothrombin time or activated partial thromboplastin time higher than normal thresholds) or oral anticoagulants (warfarin, newer anticoagulants such as rivaroxaban, or dabigatran, among others) for other medical reasons, (11) alcohol or opioid abuse in the last 2 months. (12) Uncontrolled anxiety, schizophrenia and other psychiatric disorders, or inability to cooperate with follow-up visits or telephone calls (13) Pregnancy or pregnancy preparation, (14) History of allergy to local anaesthetics or any experimental drugs, (15) History of thoracic surgery, (16) Intraoperative mid-operative open chest, (17) Distant metastases at the time of diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| chronic postsurgical pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| chronic postsurgical pain;Pain within 3 days after surgery;Quality of recovery 24 hours after surgery;Sleep quality 24 hours after surgery;First rescue analgesia time;First time out of bed;Incidence of postoperative nausea and vomiting;Incidence of postoperative pulmonary complications;Total length of hospital stay;Hospitalisation costs; | — |
Countries
China
Contacts
Public ContactXiaoqiang Li
West China Hospital, Sichuan University
Outcome results
None listed