Chronic viral hepatitis B
Conditions
Interventions
(very)low-level viremia group/complete virological response group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old; 2. Patients who have received TDF, ETV, or TAF treatment for no less than 12 months and have a ordinary HBV DNA<100IU/ml; 3. Before antiviral treatment, the serum hepatitis B surface antigen remains positive for 6 months or more.
Exclusion criteria
Exclusion criteria: 1. Lack of baseline clinical data; 2.Co-infection with other viral hepatitis or human immunodeficiency virus; 3. Co-existing with drug-induced liver disease, hereditary liver disease, autoimmune hepatitis, and other serious diseases; 4. History of HCC or other malignant tumors; 5. Combined treatment with other antiviral drugs, such as ETV+TDF, nucleoside analogues+interferon; 6. Failed to complete two consecutive hyper-sensitivity HBV DNA tests (with a lower limitation of 10IU/ml)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBV DNA seroconversion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| change of APRI;change of FIB-4 score;ALT normalization rate;Incidence of cirrhosis;Incidence of liver cancer; | — |
Countries
China
Contacts
Public ContactChen Enqiang
West China Hospital, Sichuan University
Outcome results
None listed