Metabolic-related fatty liver disease
Conditions
Interventions
Sponsors
Wuxi Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the health group: (1) Age: 18-60 years old; (2) No gender restrictions; (3) Patients who have signed informed consent forms. (4) FAP240 db/m, and the diagnosis conforms to the International Expert Consensus on Metabolic Related Fatty Liver Disease (2020);
Exclusion criteria
Exclusion criteria: Exclusion criteria for healthy population group: (1) Those who do not meet the inclusion criteria; (2) Individuals under the age of 18 or over 60 years old; (3) Used antibiotics within one month prior to enrollment and refused to discontinue medication for elution; Currently, patients taking probiotics, gastrointestinal motility drugs, and other preparations that can affect gut microbiota; (4) There are contraindications for fibrotouch and colonoscopy examination; (5) Patients with mental or legal disabilities; (6) Women of childbearing age who are preparing to become pregnant during the study period; (7) Patients with severe diseases of important organs such as heart, brain, lungs, liver, and kidneys; (8) The patient participated in other clinical trials within 3 months; (9) Researchers believe that other patients are not suitable for inclusion. Exclusion criteria for fatty liver group: (1) Those who do not meet the inclusion criteria; (2) Individuals under the age of 18 or over 60 years old; (3) Alcohol consumption history>5 years, equivalent to ethanol intake = 40g/d for males and = 20g/d for females; Or have a history of heavy alcohol consumption within 2 weeks, equivalent to an ethanol level greater than 80g/d; (4) Specific diseases that can lead to fatty liver, such as viral hepatitis, drug-induced liver disease, genetic factors, etc; (5) Used antibiotics within one month prior to enrollment and refused to discontinue medication for elution; Currently, patients taking probiotics, gastrointestinal motility drugs, and other preparations that can affect gut microbiota; (6) There are contraindications for fibrotouch and colonoscopy examination; (7) Patients with mental or legal disabilities; (8) Women of childbearing age who are preparing to become pregnant during the study period; (9) Patients with severe diseases of important organs such as heart, brain, lungs, liver, and kidneys; (10) The patient participated in other clinical trials within 3 months; (11) Researchers believe that other patients are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| liver ultrasound fibroscan ;liver function;16s rDNA sequencing of intestinal microbiota; | — |
Countries
China
Contacts
Public ContactWei Taotao
Wuxi Hospital of Traditional Chinese Medicine
Outcome results
None listed