Granulocyte deficiency with fever
Conditions
Interventions
Different subgroups of patients with neutropenia and fever:None
Sponsors
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged 18 years or older. 2) Patients diagnosed with neutropenia accompanied by fever. The diagnosis of neutropenia accompanied by fever meets the definition in the "Chinese Clinical Application Guidelines for Antimicrobial Drugs in Patients with Neutropenia and Fever (2020 Edition)": (1) Neutropenia - refers to an absolute neutrophil count (ANC) in peripheral blood <0.5×10^9/L, or expected ANC <0.5×10^9/L within 48 hours; (2) Fever - refers to a single oral temperature =38.3°C (axillary temperature =38.0°C), or an oral temperature =38.0°C (axillary temperature =37.7°C) lasting more than 1 hour. Patients with poor general condition (especially the elderly patients) without fever or showing hypothermia can also be included. 3) The patient has received Eravacycline treatment at least 3 days or more.
Exclusion criteria
Exclusion criteria: 1) Clearly identified as neutropenia accompanied by fever caused by a single strain of Pseudomonas Aeruginosa. 2) Pregnant women and nursing mothers are advised that the investigator should choose based on the actual clinical situation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety;Characteristics of the target patients;Prescription status of Eravacycline; | — |
Countries
China
Contacts
Public ContactSizhou Feng
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed