Thyroid cancer
Conditions
Interventions
Ondansetron Formation:8 mg of ondansetron was administered orally 1 hour before anesthesia, followed by two doses of the drug at 8-hour intervals
The Aprepitane Group:Aprepitant 125 mg orally 1 hour before anesthesia and 80mg orally once daily on the morning of the 2nd and 3rd day after surgery (day 1 on the day of surgery)
Combination group:Aprepitant 125 mg plus 8 mg ondansetron was administered orally 1 hour before anesthesia, followed by ondansetron twice every 8 hours, and Aprepitant 80mg once daily on the morning o
Sponsors
First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18-80 years; 2) Voluntarily join the study and sign the informed consent; 3) Patients diagnosed with thyroid cancer requiring surgical treatment;
Exclusion criteria
Exclusion criteria: 1) The patient has a history of depression, chronic pain, islet dependent diabetes I or II, and severe vomiting; 2) Previous history of thyroid or neck surgery; 3) Sternotomy is expected to be performed; 4) Long-term hormone use history, immunosuppressive treatment period; 5) Voice has changed before surgery or laryngoscopy confirms vocal cord paralysis; 6) Pregnant or breastfeeding patients; 7) Patients who are allergic to any investigational drug; 8) Received any sedation, hypnosis, anti-anxiety drugs, opioids, steroids in the 24 hours prior to surgery Or other anti-emetic drugs; 9) is taking or planning to take in combination such as rifampicin, carbamazepine, phenytoin or other strong induction CYP3A4 active drug; 10) Combined with other malignant tumors; 11) Patients with hypothyroid function; 12) Are or plan to participate in other clinical investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate with no vomiting and no rescue within 24 hours after surgery (CR rate); | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete response rate with no vomiting and no rescue within 48 hours after surgery (CR rate);There was no vomiting rate in 24h and 48h;There is no rescue rate within 24h and 48h;When vomiting or nausea first occurs;Evaluation of nausea within 24h and 48h after surgery;The number of postoperative vomiting within 24h and 48h; | — |
Countries
China
Contacts
Public ContactYin detao
First Affiliated Hospital of Zhengzhou University
Outcome results
None listed