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An exploratory study on dynamic monitoring of MRD for therapeutic efficacy and prognosis in patients with extensive-small cell lung cancer

An exploratory study on dynamic monitoring of MRD for therapeutic efficacy and prognosis in patients with extensive-small cell lung cancer

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400089321
Enrollment
Unknown
Registered
2024-09-05
Start date
2024-09-05
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Small cell lung cancer

Interventions

Observation group:N/A

Sponsors

Jilin Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Sign informed consent; 2. Age =18 years old; 3. ES-SCLC with histologically confirmed and initially treated (any T, any N, M1a/b/c, or T3-4 that cannot be included in a tolerable radiotherapy schedule due to multiple nodules in the lungs or tumor/nodules too large); 4. The Eastern Cooperative Oncology Group (ECOG) score: 0-2; 5. Have at least one measurable lesion according to RECIST version 1.1; 6. Plan to receive first-line treatment with immunotherapy plus chemotherapy regimen; 7. Provide tumor tissue samples and blood samples.

Exclusion criteria

Exclusion criteria: 1. Mixed SCLC confirmed by histology or cytology; 2. Patients who refuse to receive first-line treatment; 3. A history of other malignant tumors in the past 5 years (cured localized tumors, such as skin base cell carcinoma, skin squamous cell carcinoma, superficial bladder carcinoma, prostate carcinoma in situ, cervical carcinoma in situ, and breast carcinoma in situ were eligible for inclusion).

Design outcomes

Primary

MeasureTime frame
Measurable Residual Disease;

Countries

China

Contacts

Public ContactCheng Ying

Jilin Cancer Hospital

jl.cheng@163.com+86 139 4301 2851

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026