Comparison of oliceridine and sufentanil in postoperative nausea and vomiting in patients undergoing radical mastectomy for breast cancer:a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400089317

Enrollment

Unknown

Registered

2024-09-05

Start date

2024-09-10

Completion date

Unknown

Last updated

2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Oliceridine group :Anesthesia induction was administered according to the assigned group, Group O: Anesthesia induction was achieved by intravenous midazolam (0.03 mg/kg), propofol (2 mg/kg), Oliceri

sufentanil group:Group S: Midazolam (0.03 mg/kg), propofol (2 mg/kg), sufentanil (0.4 µg/kg) and rocuronium bromide (0.6 mg/kg) were used to achieve anesthetic induction.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) All female patients were 18 to 75 years old, weighing =45 kg and BMI =40 kg/m2 patients; (2) Patients undergoing radical mastectomy for breast cancer; (3) Patients with American Society of Anesthesiologists ASA classification I-III; (4) Complete patient data, including: clinical data, VAS scores, and postoperative visit data.

Exclusion criteria

Exclusion criteria: (1) Patients with relevant systemic diseases (e.g., comorbid pain disorders or hepatic or renal disorders) that may affect the metabolism of opioid medications (2) Patients with clinical symptoms for which opioids are contraindicated; (3) Patients with recent and frequent use of various analgesic drugs; (4) Patients with opioid tolerance or physical dependence, or substance abuse; (5) Patients with an ASA classification of V; (6) Patients with a history of motion sickness.

Design outcomes

Primary

Measure	Time frame
Comparison of the incidence of nausea and vomiting in the 48h postoperative period between the two groups of patients;	—

Secondary

Measure	Time frame
The incidence of pain and VAS scores in resting and active states during the 48h postoperative period, and the number of cases of remedial antiemetic and analgesic; the incidence of cardiovascular adverse reactions after induction of anesthesia, such as hypotension (systolic blood pressure <90 mmHg or diastolic blood pressure <60 mmHg), bradycardia (HR <60 beats/min), and the use of vasoactive medications after the induction of anesthesia were recorded; changes in heart rate and blood pressure b;	—

Measure

Time frame

The incidence of pain and VAS scores in resting and active states during the 48h postoperative period, and the number of cases of remedial antiemetic and analgesic; the incidence of cardiovascular adverse reactions after induction of anesthesia, such as hypotension (systolic blood pressure <90 mmHg or diastolic blood pressure <60 mmHg), bradycardia (HR <60 beats/min), and the use of vasoactive medications after the induction of anesthesia were recorded; changes in heart rate and blood pressure b;

—

Countries

china

Contacts

Public ContactRui Bao

Faculty of Anesthesiology, Changhai Hospital Affiliated to The Navy Military Medical University

675357819@qq.com+86 21 3116 1869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026