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Comparison of Keverprazan-amoxicillin dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication: a prospective randomized controlled trial

Comparison of Keverprazan-amoxicillin dual therapy versus bismuth quadruple therapy for Helicobacter pylori eradication: a prospective randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089303
Enrollment
Unknown
Registered
2024-09-05
Start date
2024-09-09
Completion date
Unknown
Last updated
2024-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

helicobacter pylori

Interventions

Sponsors

Affiliated Hospital of Yangzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Subjects must meet all of the following criteria: (1) Adult patients aged 18-70 years; (2) H. pylori infected individuals diagnosed by urea breath test (UBT) or rapid urease test (RUT); (3) have not received standardized H. pylori eradication therapy before; (4) Voluntarily participate in the study and sign the informed consent.

Exclusion criteria

Exclusion criteria: Individuals who meet any of the following criteria are not eligible to participate in this study: (1) Those who have used antibiotics, bismuth preparations, probiotics, potassium-competitive acid blockers, PPIs, or H2 receptor antagonists in the past 4 weeks or potassium-competitive acid blockers, PPIs, or H2 receptor antagonists in the past 2 weeks. (2) Individuals who are allergic to the study medication. (3) Those who are concurrently using non-steroidal anti-inflammatory drugs, systemic corticosteroids, anticoagulants, or alcohol during treatment. (4) Individuals with severe heart, lung, liver, kidney, or other diseases, or compromised immune systems. (5) Those with acute upper gastrointestinal bleeding, gastrointestinal malignancies, Zollinger-Ellison syndrome, or a history of gastric cancer surgery. (6) Individuals who are pregnant or breastfeeding. (7) Those with mental illness or cognitive impairments that prevent them from cooperating.

Design outcomes

Primary

MeasureTime frame
Helicobacter pylori eradication rate;

Secondary

MeasureTime frame
Adverse events;Compliance;

Countries

China

Contacts

Public ContactYan-Bing Ding

Affiliated Hospital of Yangzhou University

ybding@yzu.edu.cn+86 137 7358 2299

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026