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Mechanism of Buccal Acupuncture Therapy Improving Postoperative Pain after Cesarean Section by Reducing Inflammatory Factor Levels through JAK2/STAT3 Pathway

Mechanism of Buccal Acupuncture Therapy Improving Postoperative Pain after Cesarean Section by Reducing Inflammatory Factor Levels through JAK2/STAT3 Pathway

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089299
Enrollment
Unknown
Registered
2024-09-05
Start date
2024-09-26
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Interventions

Control group:Intravenous patient-controlled analgesia pump
Experimental group:Intravenous patient-controlled analgesia pump+ Buccal Acupuncture Therapy, acupoints were selected, including bilateral Sanjiao, lumbar, and sacral acupoints.

Sponsors

Guangzhou Women and Children's Medical Center Liuzhou Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (1) Postpartum women aged 20-40 who have undergone cesarean section; (2) Pregnancy weeks are 37-41 weeks, parity = 3, and parity = 4; (3) No history of adverse pregnancy and childbirth, no pregnancy complications; (4) The American Society of Anesthesiologists (ASA) classifies physical condition into grades I-II; (5) Having systematic prenatal care and no underlying diseases; (6) Voluntarily participate in this research project and sign an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Those who do not meet the inclusion criteria; (2) Individuals with contraindications to anesthesia; (3) Patients who experience major bleeding or serious complications during surgery; (4) Individuals with mental disorders and cognitive impairments; (5) Those with poor compliance and inflammation or damage at the acupoint operation site.

Design outcomes

Primary

MeasureTime frame
Visual Analog Scale (VAS) score;Levels of inflammatory cytokines in peripheral blood and expression levels of serum JAK2/STAT3 pathway proteins;

Secondary

MeasureTime frame
The number of compressions of the intravenous patient-controlled analgesia pump, the time of first anal exhaust, the time of first urination, and the time of getting out of bed activity;Adverse reaction indicators;

Countries

China

Contacts

Public ContactHu Jing

Guangzhou Women and Children's Medical Center Liuzhou Hospital

15077202268@139.com+86 150 7720 2268

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026