hyperactivity
Conditions
Interventions
Experimental group:Oral lithium extended-release treatment, 5 mg/kg, twice daily, 12 hours apart, for 3 months, discontinued for 3 months.
Control group 1:Administered oral placebo calcium carbonate based on conventional rehabilitation training
Control group 2:Only receive treatment with methylphenidate
Combination therapy group:Treatment with methylphenidate in addition to oral lithium extended-release
Sponsors
Zhengzhou University Third Affiliated Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 14 Years
Inclusion criteria
Inclusion criteria: Children aged 6 to 14 years with a definite diagnosis of ADHD were included if they were 1) aged 6 to 14 years inclusive at the time of parental informed consent; 2) male or female; 3) had a DSM-V confirmed diagnosis of ADHD (any manifestation) at screening and were determined by SNAP-IV; 4) were not receiving medication with methylphenidate or amphetamines at that time; or were receiving medication and had to be willing and appropriate (ie, receive the best treatment at the investigator 's discretion) to washout current treatment regimen.
Exclusion criteria
Exclusion criteria: Exclusion criteria : 1) Patients who are currently receiving non-stimulant drugs for ADHD (i.e. atomoxetine, clonidine, guanfacine, etc.); 2) Complications of inherited metabolic diseases or autoimmune/inflammatory diseases; 3) Epilepsy; 4) History of febrile convulsions, fever or other infectious symptoms; 5) Taking any drug that can cause cognitive changes and important organ damage within 1 month before medication; 6) Any other physical and mental disorders that can lead to brain dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Near Infrared Functional Brain Imaging;ADHD-RS;IVA;SNAP-IV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram;Weiss;Conners;Intelligence assessment (Wechsler);S-S;QCD;PRS;PSI; | — |
Countries
China
Contacts
Public Contactchanglian zhu; Yiran Xu
Zhengzhou University Third Affiliated Hospital
Outcome results
None listed