Type II diabetes
Conditions
Interventions
Gold Standard:Neuropsychological Assessment Scale, biomarkers, imaging.
Index test:Montreal Cognitive Assessment,mini-mental state examination,Eye-tracking data,Differential gene analysis
Sponsors
Zhejiang Rehabilitation Medical Center
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for the Chinese Guidelines for the Prevention and Control of Type 2 Diabetes Mellitus (2022 edition): (1) Fasting plasma glucose =7.0 mmol/L (confirmed by repeat testing on a subsequent day in the absence of unequivocal hyperglycemia symptoms) (2) Classic symptoms of diabetes (polydipsia, polyuria, polyphagia, unexplained weight loss) + random plasma glucose or venous plasma glucose =11.1 mmol/L; (3) 2-hour plasma glucose during 75g oral glucose tolerance test (OGTT) =11.1 mmol/L (confirmed by repeat testing on a subsequent day in the absence of unequivocal hyperglycemia symptoms); (4) Glycated hemoglobin (HbA1c) =6.5% 2. MMSE score =17 (no education), =20 (1-6 years of education), =24 (more than 7 years of education), and MoCA score =13 (no education), =19 (1-6 years of education), =24 (more than 7 years of education); report cognition impairment by themselves, family members and doctor. 3. Normal people without psychiatric or neurological disorders, with normal cognitive functioning and MMSE scores greater than 25.
Exclusion criteria
Exclusion criteria: Organic lesions in the brain (such as brain tumors, cerebral infarction, hemorrhage, or vascular malformations); history of epilepsy, traumatic brain injury, and craniotomy; history of mental disorders (such as depression, schizophrenia, etc.); systemic organic diseases (such as uremia, etc.) or history of extracranial tumors; moderate to severe hypertension (systolic blood pressure =160 mmHg or diastolic blood pressure =100 mmHg), glaucoma, high myopia, and other conditions that prevent the completion of eye movement experiments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Mini-mental state examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Staring time;Saccade count;Saccade amplitude;Saccade frequency;Search time; | — |
Countries
China
Contacts
Public ContactGao Yuan
Zhejiang Rehabilitation Medical Center
Outcome results
None listed