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Comparison of liposome bupivacaine and cocktail analgesic regimens for postoperative analgesia in Posterior cervical open-door laminoplasty: a prospective, double-blind, randomized controlled clinical study

Comparison of liposome bupivacaine and cocktail analgesic regimens for postoperative analgesia in Posterior cervical open-door laminoplasty: a prospective, double-blind, randomized controlled clinical study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400089274
Enrollment
Unknown
Registered
2024-09-05
Start date
2024-09-10
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Degenerative disease of the cervical spine

Interventions

A:The patient was given intraoperative local infiltration analgesia using a cocktail consisting of the traditional local anaesthetic ropivacaine (including: ropivacaine 200mg, epinephrine 0.2mg, dexam
B:Patients were treated intraoperatively with bupivacaine liposome solution (containing bupivacaine liposome 266 mg, diluted using saline for a total of 120 ml) for local infiltration analgesia

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The patient was diagnosed with multi-segmental cervical stenosis caused by a multi-segmental cervical disc herniation and ossification of the posterior longitudinal ligament of the cervical spine requiring posterior cervical laminoplasty; 2. Patients were =18 and =80 years old; 3. The patient does not have any congenital diseases and other underlying conditions that can bring about chronic pain; 4. Patients and their guardians agreed to participate in the study and signed the relevant informed consent form;

Exclusion criteria

Exclusion criteria: 1. The patients are those who have poor general condition and cannot accept the operation; those who have a long course of disease, the spinal cord has been degenerated, the muscles of the limbs are atrophied, and the function of the cervical vertebrae is seriously impaired; 2. The patient receives a secondary revision surgery; 3. Patients with significant segmental instability of the cervical spine, especially in cases where there is damage or lesions to the anterior structures that have not yet recovered; 4. The patient is less than 18 years old or more than 80 years old; 5. patients and their families refused to participate in this study;

Design outcomes

Primary

MeasureTime frame
Postoperative dosage of remedial morphine hydrochloride;Time to first postoperative remedial analgesia;VAS pain score;

Secondary

MeasureTime frame
Postoperative drainage and urinary tube removal time;Daily walking distance;Postoperative cervical mobility;The duration of hospital stay;Incidence of postoperative complications;

Countries

China

Contacts

Public ContactLei Wang

West China Hospital, Sichuan University

wanglei_cd@126.com+86 189 8060 6658

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026