Acute ischemic stroke
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Ages = 18 years; 2. Present less than 24 hours of stroke onset or last seen well; 3. Clinical diagnosis of AIS due to posterior circulation large vessel occlusion on DSA/CTA/MRA; 4. Alberta Stroke Program Early CT Score (ASPECTS)=5 on CT/MRI; 5. National Institute of Health stroke scale (NIHSS) =6; 6. Informed consent obtained from patients or their legal representatives.
Exclusion criteria
Exclusion criteria: 1. Confirmed intracranial hemorrhage through computed tomography (CT) or magnetic resonance imaging (MRI); 2. Received Intravenous Thrombolysis; 3. Pre-stroke modified Rankin Scale (mRS) score = 2; 4. Pregnancy or breastfeeding women; 5. Allergy to contrast agents; 6. Currently participating in other clinical trials; 7. Systolic blood pressure > 185mmHg or diastolic blood pressure > 110mmHg, and oral antihypertensive drugs cannot control it; 8. Genetic or acquired bleeding diathesis, deficiency of anticoagulant factors, or use of anticoagulant medication with an International Normalized Ratio (INR) > 3; 9. Blood glucose 22.2mmol/L (400mg/dl),platelets <100*10^9/L or Hct<25%; 10. History of bleeding within the past month; 11. Any end-stage disease with expected survival less than 6 months; 12. Anticipated inability to complete follow-up; 13. Intracranial aneurysm, arteriovenous malformation; 14. Presence of intracranial tumors with mass effect on imaging (excluding small meningiomas); 15. Brain herniation causing midline shift; 16. Presence of severe complications that may affect patient prognosis and follow-up (cancer, severe heart failure, renal failure). <br
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shift in the distribution of mRS scores at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of 90-day modified Rankin scale (mRS) score 0-3(%);The rate of 90-day modified Rankin scale (mRS) score 0-2(%);The rate of 90-day modified Rankin scale (mRS) score 0-1(%);EQ-5D scale score;Symptomatic intracranial hemorrhage;any intracranial hemorrhage;The rate of death; | — |
Countries
China
Contacts
Public ContactZi Wenjie
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed