Postoperative Nausea and Vomiting
Conditions
Interventions
Oliceridine Group:Oselidine 0.05mg/kg was used for anesthesia induction, 1mg of oselidine was added every 2 hours and 10 minutes before the end of the operation, and oselidine 0.4mg/kg was used for po
Sufentanil Group:Sufentanil 0.5 µg/kg was used for anesthesia induction, 10 µg of sufentanil was added every 2 hours and 10 minutes before the end of the operation, and sufentanil was used 2 µg/kg for
Sponsors
Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-65 years; 2) ASA grade I-III; 3) BMI 18.5-23.9 kg/m²; 4) Patients undergoing elective general abdominal surgery who require postoperative patient-controlled intravenous analgesia (PCIA); 5) Voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Chronic pain, long-term use of analgesics and psychotropic drugs, or alcohol abuse; 2) Allergy to the study drug or any contraindications; 3) Patients in shock, with mental abnormalities, or cognitive impairment who cannot cooperate; 4) Severe heart disease, liver disease, or kidney disease; 5) Acute or chronic bronchial asthma; 6) Suspected gastrointestinal obstruction; 7) Prolonged QT interval on ECG or presence of ventricular arrhythmias; 8) Concurrent use of drugs known to prolong the QT interval (e.g., moxifloxacin, quinidine, amiodarone, etc.); 9) Untreated hypokalemia or hypomagnesemia; 10)P regnancy, breastfeeding, or planned pregnancy; 11) Sleep apnea; 12) Participation in other drug trials within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting (PONV) within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of vomits within 48 hours after surgery.;The degree of nausea within 48 hours after surgery;The dose and proportion of patients using antiemetics within 48 hours after surgery;Resting NRS pain score within 48 hours after surgery;The dose and proportion of patients using rescue analgesics within 48 hours after surgery;The number of effective presses and drug consumption of the analgesia pump;Incidence of other opioid-related adverse reactions: Hypoxemia depression, pruritus, dizziness, headache;Time to first postoperative flatus;Quality of recovery after surgery (QoR-15 score);Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactXu Tao
Changhai Hospital
Outcome results
None listed