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Etiology and prognosis of acute liver failure in Chinese children: a multicenter bidirectional observational cohort study

Etiology and prognosis of acute liver failure in Chinese children: a multicenter bidirectional observational cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400089260
Enrollment
Unknown
Registered
2024-09-04
Start date
2024-10-01
Completion date
Unknown
Last updated
2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pediatric acute liver failure

Interventions

Retrospective observatio group:none

Sponsors

The First Hospital of Jilin University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 18 Years

Inclusion criteria

Inclusion criteria: (1) Refer to the diagnostic criteria of PALF, namely: ? Sudden severe abnormal liver biochemical indexes within 8 weeks; Thrombin time (PT) was higher than 15s or international normalized ratio (INR) was higher than 1.5 during hepatic encephalopathy. With and without hepatic encephalopathy PT > 20s or INR > 2.0. (2) For patients admitted twice, only the case information of the first hospitalization was used. (3) The acute onset of chronic liver disease (genetic metabolic factors, drug factors, etc.) or biliary obstruction in the past is classified as acute liver failure. (4) The legal guardian of the child has signed a written informed consent

Exclusion criteria

Exclusion criteria: (1) Age >18 years old; (2) There are serious data missing (>10%); (3) The legal guardian of the child refuses to participate.

Design outcomes

Primary

MeasureTime frame
clinical outcomes at discharge;

Secondary

MeasureTime frame
Discharge status;Long term survival situation;

Countries

China

Contacts

Public ContactLi Yumei

Department of PICU, the First Hospital of Jilin University

ym_li@jlu.edu.cn+86 158 0430 2907

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026