end-stage liver disease with splenomegaly
Conditions
Interventions
Control group:Routine liver transplantation surgery
Experimental group:Routine liver transplantation surgery with intraoperative splenic artery ligation
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.end-stage liver disease meet criterion of liver transplantation; 2.sign informed consent independently; 3.splenomegaly (>Five intercostal Spaces in CT scan).
Exclusion criteria
Exclusion criteria: 1. The recipient's hepatic artery and splenic artery are not from a common trunk; 2. The splenic artery cannot be dissected or freed; 3. Poor hepatic artery condition (weak fluctuation after arterial anastomosis (right hepatic artery flow rate 10 hours); 5. Split or reduced-size liver transplantation; 6. Recipient with expected survival not exceeding 6 months; 7. HIV or acute tuberculosis infection; 8. Recipient requiring biliary-enteric anastomosis; 9. Previous liver transplantation or requiring combined transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-anastomotic biliary stricture; | — |
Secondary
| Measure | Time frame |
|---|---|
| Abdominal infection;ICU duration and in-hospital duration after transplantation;Postoperative complications;Vascular complications;Early allograft dysfunction;Blood flow changes in the hepatic artery and portal vein main trunks before and after splenic artery ligation;Platelet improvement;Surgical duration;Splenic abscess;1-year and 3-year survival rates;NAS or death within 6 months after liver transplantation;Sepsis;primary non-function;new onset diabetes after transplantation, NODAT;anastomotic biliary strictures,AS;The severity of NAS;highest total bilirubin and INR 7 days after transplantation;pancreatitis;bile leakage;Onset time of NAS;splenic artery aneurysm;highest ALT and AST 7 days after transplantation; | — |
Countries
China
Contacts
Public ContactLeida Zhang
The First Affiliated Hospital of Army Medical University
Outcome results
None listed